Archive

Posts Tagged ‘Glutathione’

Depression and Glutathione

August 11th, 2009

Many of us suffer from bouts of depression from time to time, and depression has a detrimental effect on memory. I found a study on depression and glutathione discussed at GlutathioneDiseasaeCure.com and referenced at PubMed.gov.

The Glutathione Treatments for Depression

The glutathione treatments for depression provides a simple easy way to eliminate for some, what is a debilitating condition.

Many have discovered what seems to be an effective depression treatment … This treatment for depression is actually backed up with science. It is simply boosting glutathione with supplemental cysteine intake.

First consider what a study from Biological Psychiatry has to say.

Cysteine for Depressive Symptoms is an published study in Biological Psychiatry, November, 2008 1;64(9):e1.

The full title: N-acetyl cysteine for depressive symptoms in bipolar disorder–a double-blind randomized placebo-controlled trial. The study noted that both depression and bipolar disorder are complicated by glutathione depletion. They started with the premise that N-acetyl cysteine (NAC), a precursor of glutathione, could improve the depressive felt in bipolar disorder.

The study was randomized, double blind multi-center placebo study of people with bipolar disorder. They were treated with NAC given adjunctive to their usual treatment.

They were measured on a depression rating scale, a time to a mood episode, Bipolar Depression Rating Scale and 11 other ratings of clinical status including quality of life, and functioning.

The study found that NAC treatment resulted in significant improvement. In all but one of the measurements it worked in a frame of 2 to 20 weeks. The depression treatments were found results considered good to great in over 3/4 of the measurements.

You will read in the abstract that the conclusion was that NAC appears to be a safe and effective augmentation strategy for depressive symptoms in bipolar disorder.

However there was a flaw in the study. Well, a flaw of sorts.

The method of administration of NAC and the effectiveness of the NAC was limited to the quality of what would be typically purchased over the counter at a health food store.

There currently are patented formulations of NAC and Cysteine that have been clinically proven to boost glutathione far above the levels that can be obtained from just the generic variety of NAC.

In effect, the NAC is augmented to be more effective. To be sure, most people give it at least a month to two months to see if it is effective for them. Although many will find it works in three days to a week, numerous anecdotal experiences have found that it can take up to two months to realize the full effectiveness.

The effectiveness of these alternative treatments for depression come from a novel approach. Help the body to get into a state of health and the mental health will follow on its own.

Bottom line, be patient. What do you have to lose, well, besides your depression.

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You can raise the glutathone level in every one of your cells by ingesting MaxGXL.

Susan Juricek Uncategorized , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

Alcoholism and Low Glutathione

August 5th, 2009

Effects of Chronic Hepatic Dysfunction on Pulmonary Glutathione Homeostasis

Alcoholism: Clinical & Experimental Research. 26(12):1840-1845, December 2002.
Foreman, Marilyn G.; Hoor, Terri Ten; Brown, Lou Ann S.; Moss, Marc

Abstract:
Background: The development of acute respiratory distress syndrome (ARDS) in patients with pre-existing cirrhosis of the liver is associated with very high mortality. One possible cause may be alteration of pulmonary antioxidant capacity as a result of chronic hepatic dysfunction. Glutathione (GSH) is the most substantial nonprotein thiol in living organisms and likely plays a key role in neutralizing the oxidants and reactive oxygen species that are increased in ARDS. The lung is unable to synthesize GSH and is dependent on the liver. During periods of oxidant stress, individuals may exhibit relative deficiencies of GSH. With cirrhosis, the end result of chronic alcohol ingestion, this deficiency is more profound.

Methods: Sixteen stable subjects with cirrhosis primarily due to alcohol consumption and 15 healthy controls underwent bronchoscopy and bronchoalveolar lavage with concurrent measurement of GSH in the plasma and the alveolar epithelial lining fluid (ELF).

Results: For standardizing for saline dilution of the epithelial lining fluid as a result of bronchoalveolar lavage, GSH values are expressed in relation to immunoglobulin A (IgA). GSH in the ELF was profoundly reduced in the cirrhotic group [12.5 [mu]g of GSH per [mu]g of IgA (5.3-16.9 [mu]g)] compared with the control group [64.0 [mu]g of GSH per [mu]g of IgA (55.1-242.5 [mu]g);p < 0.001]. The ratio of oxidized GSH to total GSH in the ELF was also significantly increased in the cirrhotic group [9.2% (5.1-16.4%) vs. 3.4% (1.7-5.7%);p < 0.003]

Conclusions: Despite a total reduction in GSH concentrations in the alveolar epithelial lining fluid of individuals with cirrhosis, the amount of oxidized GSH is increased. There is increased utilization of GSH despite the low supply in stable individuals with cirrhosis during steady state. These perturbations in GSH homeostasis in the alveolar epithelial lining fluid may be a factor in the poor outcomes seen in these individuals with ARDS.

2002 Research Society on Alcoholism

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What does this mean for those of us who are alcoholic or have alcoholic loved ones? Chronic alcoholism results in low levels of glutathione and in cirrhosis of the liver. Cirrhosis further depletes glutathione levels. Even though levels are down, there continues to be an increase in the amount of glutathione that the body uses (logically, this will further deplete supplies of the body’s primary antioxident). Disruptions in glutathione equilibrium in the alveolar epithelial lining fluid may be a factor in the poor outcomes seen in these individuals with ARDS.

Learn more about glutathione.

Susan Juricek Uncategorized , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

Will I Get Alzheimer’s Disease if One of My Parents Has It?

July 29th, 2009

While there are genetic risk factors for Alzheimer’s disease, the question of risk related to a family history of Alzheimer’s is a complicated area of ongoing research. Most cases of Alzheimer’s…up to 75%…are not inherited, especially those cases where the disease starts at an older age. So, chances are that my risk is not too much higher than that of the general public, even though my mother died from the disease two years ago.

That said, anyone who has a first-degree relative (mother, father, brother, or sister) who had Alzheimer’s has an increased risk of getting the disease — probably because of shared genes. Since we can do absolutely nothing about the genes with which we were born, it is up to us to take preventive measures. The prevailing medical opinion is that the steps for preventing  Alzheimer’s are the same as those for preventing heart disease: healthy diet, exercise, and keeping blood pressure and cholesterol under control. Some research also suggests that keeping your mind active doing puzzles, playing games, reading, going to museums, etc. is helpful in preventing Alzheimer’s. In other words, staying active professionally, socially and physically is one of the best things you can do to keep your brain healthy and delay the onset of Alzheimer’s.

The symptoms of Alzheimer’s (cognitive problems with thinking, speaking, reasoning, understanding, remembering, planning, and demonstrating good judgment) are only one part of the prevention puzzle. Other parts also need to be considered — there is an association with Alzheimer’s disease symptoms and a lack of glutathione in the brain.

Susan Juricek Uncategorized , , , , , , , , , , , , , , , , , , , , , , , , , ,

Good News About Age-Related Cognitive Decline in Baby Boomers!

May 18th, 2009

The bad news is that we live in an era when even young, agile brains are experiencing information overload. Constantly bombarded by info from TVs, newspapers, magazines, faxes, email, and non-ending data posted on the internet, I, for one, often think that too much is being required of my once considerable (now waning) mental powers.

The good news is that science continues to learn new ways to boost even the aging brain’s performance. Science now has a detailed picture of how the intricate machinery of the brain functions…and this makes it much easier for baby boomers to take a variety of supplements to give us the nutritional, neuro-chemical, and hormonal substances necessary for optimal brain performance. I suggest that careful, intelligent use of natural supplements can improve memory and help our aging brains adapt to today’s information overload.

Susan Juricek Uncategorized , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,