Depression and Glutathione

August 11th, 2009

Many of us suffer from bouts of depression from time to time, and depression has a detrimental effect on memory. I found a study on depression and glutathione discussed at GlutathioneDiseasaeCure.com and referenced at PubMed.gov.

The Glutathione Treatments for Depression

The glutathione treatments for depression provides a simple easy way to eliminate for some, what is a debilitating condition.

Many have discovered what seems to be an effective depression treatment … This treatment for depression is actually backed up with science. It is simply boosting glutathione with supplemental cysteine intake.

First consider what a study from Biological Psychiatry has to say.

Cysteine for Depressive Symptoms is an published study in Biological Psychiatry, November, 2008 1;64(9):e1.

The full title: N-acetyl cysteine for depressive symptoms in bipolar disorder–a double-blind randomized placebo-controlled trial. The study noted that both depression and bipolar disorder are complicated by glutathione depletion. They started with the premise that N-acetyl cysteine (NAC), a precursor of glutathione, could improve the depressive felt in bipolar disorder.

The study was randomized, double blind multi-center placebo study of people with bipolar disorder. They were treated with NAC given adjunctive to their usual treatment.

They were measured on a depression rating scale, a time to a mood episode, Bipolar Depression Rating Scale and 11 other ratings of clinical status including quality of life, and functioning.

The study found that NAC treatment resulted in significant improvement. In all but one of the measurements it worked in a frame of 2 to 20 weeks. The depression treatments were found results considered good to great in over 3/4 of the measurements.

You will read in the abstract that the conclusion was that NAC appears to be a safe and effective augmentation strategy for depressive symptoms in bipolar disorder.

However there was a flaw in the study. Well, a flaw of sorts.

The method of administration of NAC and the effectiveness of the NAC was limited to the quality of what would be typically purchased over the counter at a health food store.

There currently are patented formulations of NAC and Cysteine that have been clinically proven to boost glutathione far above the levels that can be obtained from just the generic variety of NAC.

In effect, the NAC is augmented to be more effective. To be sure, most people give it at least a month to two months to see if it is effective for them. Although many will find it works in three days to a week, numerous anecdotal experiences have found that it can take up to two months to realize the full effectiveness.

The effectiveness of these alternative treatments for depression come from a novel approach. Help the body to get into a state of health and the mental health will follow on its own.

Bottom line, be patient. What do you have to lose, well, besides your depression.

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You can raise the glutathone level in every one of your cells by ingesting MaxGXL.

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Alcoholism and Low Glutathione

August 5th, 2009

Effects of Chronic Hepatic Dysfunction on Pulmonary Glutathione Homeostasis

Alcoholism: Clinical & Experimental Research. 26(12):1840-1845, December 2002.
Foreman, Marilyn G.; Hoor, Terri Ten; Brown, Lou Ann S.; Moss, Marc

Abstract:
Background: The development of acute respiratory distress syndrome (ARDS) in patients with pre-existing cirrhosis of the liver is associated with very high mortality. One possible cause may be alteration of pulmonary antioxidant capacity as a result of chronic hepatic dysfunction. Glutathione (GSH) is the most substantial nonprotein thiol in living organisms and likely plays a key role in neutralizing the oxidants and reactive oxygen species that are increased in ARDS. The lung is unable to synthesize GSH and is dependent on the liver. During periods of oxidant stress, individuals may exhibit relative deficiencies of GSH. With cirrhosis, the end result of chronic alcohol ingestion, this deficiency is more profound.

Methods: Sixteen stable subjects with cirrhosis primarily due to alcohol consumption and 15 healthy controls underwent bronchoscopy and bronchoalveolar lavage with concurrent measurement of GSH in the plasma and the alveolar epithelial lining fluid (ELF).

Results: For standardizing for saline dilution of the epithelial lining fluid as a result of bronchoalveolar lavage, GSH values are expressed in relation to immunoglobulin A (IgA). GSH in the ELF was profoundly reduced in the cirrhotic group [12.5 [mu]g of GSH per [mu]g of IgA (5.3-16.9 [mu]g)] compared with the control group [64.0 [mu]g of GSH per [mu]g of IgA (55.1-242.5 [mu]g);p < 0.001]. The ratio of oxidized GSH to total GSH in the ELF was also significantly increased in the cirrhotic group [9.2% (5.1-16.4%) vs. 3.4% (1.7-5.7%);p < 0.003]

Conclusions: Despite a total reduction in GSH concentrations in the alveolar epithelial lining fluid of individuals with cirrhosis, the amount of oxidized GSH is increased. There is increased utilization of GSH despite the low supply in stable individuals with cirrhosis during steady state. These perturbations in GSH homeostasis in the alveolar epithelial lining fluid may be a factor in the poor outcomes seen in these individuals with ARDS.

2002 Research Society on Alcoholism

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What does this mean for those of us who are alcoholic or have alcoholic loved ones? Chronic alcoholism results in low levels of glutathione and in cirrhosis of the liver. Cirrhosis further depletes glutathione levels. Even though levels are down, there continues to be an increase in the amount of glutathione that the body uses (logically, this will further deplete supplies of the body’s primary antioxident). Disruptions in glutathione equilibrium in the alveolar epithelial lining fluid may be a factor in the poor outcomes seen in these individuals with ARDS.

Learn more about glutathione.

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A Passage from Dr. Bates Alternative Therapies for ADD/ADHD and Autism

August 4th, 2009

“There is a supplement specifically designed to raise Glutathione levels in the body.  Glutathione is a natural combination of amino acids that is a powerful anti-oxident with several other interesting features:
•    It’s a major part of the immune system often overlooked by scientists.
•    Glutathione detoxifies the body by taking poisons, including mercury and other toxic minerals out.  (Similar to chelation, but most other toxins as well as minerals.)
•    It’s not absorbed well when taken as a direct supplement.  This is important as there are many supplements that contain glutathione that are not generally effective.
•    Low levels of glutathione are found in all ADD/ADHD/autistic children, as well as many other sick or toxic persons.  These low levels do not allow excretion well.  This explains why hair, blood, and urine tests of mercury (and other minerals) do not show accurately what is stored in the body.
•    Price of supplement program [MaxGXL] - $85 for a 30 day supply ($69 for preferred customer).  Not cheap, but this seems to be worth the price if you can afford it. ”

For more details and to learn more about MaxGXL, go here. The potential importance of glutathione is illustrated by the huge variety of diseases associated with low glutathione levels…aging, Alzheimer’s, acne, Bird Flu and  MRSA are but a few. Do keep in mind that reduced glutathione levels does not prove that less glutathione results in the onset of  disease. Science demands a cause and effect relationship be clinically proven before such claims can be made. To date, there have been no scientifically rigorous studies to demonstate that increasing glutathione levels will improve the outcome of any disease or clinical condition. The studies have not been done because, prior to the development of MaxGXL, there was no glutathione elevating pill available (glutathione taken in pill form does not survive digestion). Nevertheless, personal experiences of folks with various conditions indicate that MaxGXL has the potential to transform the quality of life for many, many people.

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PARKINSON’S DISEASE AND LOW GLUTATHIONE

August 3rd, 2009

If you or someone you love have Parkinson’s Disease, you may want to do some research about the results people are experiencing by raising their glutathione levels (these levels can be as low as 2% of normal in PD patients). Some PD sufferers have found that symptoms greatly diminish…others that some symptoms virtually disappear.  The reduction in symptoms is a direct result of adding  glutathione to brain cells.

If you have Parkinson’s, free radical damage to your cells is already very advanced. One contributing factor is extremely low levels of glutathione, your body’s master anti-oxidant and most important free radical fighter. More studies come out every month that positively validate the connection between Parkinson’s, free radical damage, and low glutathione levels.

What Is Glutathione (see July 21 post Glutathione - the Natural Antioxidant for deeper understanding)? Glutathione is produced in every single one of your cells. It is your body’s master anti-oxidant. This means four big things:

Glutathione neutralizes free radicals.

Glutathione repairs cell damage already done by free radicals.

Glutathione can detoxify and flush toxins out of the body.

Glutathione recharges all other anti-oxidants.

Recent research analyzing the brain tissue of people with Parkinson’s has found that the damage is consistent with extensive oxidative stress. Oxidative stress IS free radical damage. Basically, the brain tissue of people living with Parkinson’s, and other neurodegenerative diseases, is ‘rusting.’ Fighting free radicals means fighting the rust. Glutathione is the master rust fighter.

Intravenous glutathione injections have been shown to have amazing and quick results in Parkinson’s. Dr. David Perlmutter, a pioneer in this therapy, developed a protocol utilized at the Perlmutter Health Center for administering intravenous glutathione to Parkinson’s patients. After even a single dose of IV glutathione - often in as little as 15 minutes - the ability to walk, turn around and move their arms is almost completely restored.

Keep in mind that adding glutathione will not cure Parkinson’s disease; but it just may substantially improve quality of life for those suffering from the condition.

So, where and how can you raise glutathione at the cellular level? The days of raising it by IV just may be gone. There is now a safe, easy method of elevating the glutathione levels in every cell of the body. The answer is MaxGXL , the only glutathione accelerator with scientifically proven effectiveness in double blind studies.

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Will I Get Alzheimer’s Disease if One of My Parents Has It?

July 29th, 2009

While there are genetic risk factors for Alzheimer’s disease, the question of risk related to a family history of Alzheimer’s is a complicated area of ongoing research. Most cases of Alzheimer’s…up to 75%…are not inherited, especially those cases where the disease starts at an older age. So, chances are that my risk is not too much higher than that of the general public, even though my mother died from the disease two years ago.

That said, anyone who has a first-degree relative (mother, father, brother, or sister) who had Alzheimer’s has an increased risk of getting the disease — probably because of shared genes. Since we can do absolutely nothing about the genes with which we were born, it is up to us to take preventive measures. The prevailing medical opinion is that the steps for preventing  Alzheimer’s are the same as those for preventing heart disease: healthy diet, exercise, and keeping blood pressure and cholesterol under control. Some research also suggests that keeping your mind active doing puzzles, playing games, reading, going to museums, etc. is helpful in preventing Alzheimer’s. In other words, staying active professionally, socially and physically is one of the best things you can do to keep your brain healthy and delay the onset of Alzheimer’s.

The symptoms of Alzheimer’s (cognitive problems with thinking, speaking, reasoning, understanding, remembering, planning, and demonstrating good judgment) are only one part of the prevention puzzle. Other parts also need to be considered — there is an association with Alzheimer’s disease symptoms and a lack of glutathione in the brain.

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